Synthesis, Characterization, and Application of Core–Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents

نویسندگان

  • Xianjin Cui
  • Domokos Mathe
  • Noémi Kovács
  • Ildikó Horváth
  • Maite Jauregui-Osoro
  • Rafael Torres Martin de Rosales
  • Gregory E. D. Mullen
  • Wilson Wong
  • Yong Yan
  • Dirk Krüger
  • Andrei N. Khlobystov
  • Maria Gimenez-Lopez
  • Mariann Semjeni
  • Krisztián Szigeti
  • Dániel S Veres
  • Haizhou Lu
  • Ignacio Hernández
  • William P. Gillin
  • Andrea Protti
  • Katalin Kis Petik
  • Mark A. Green
  • Philip J. Blower
چکیده

Multimodal nanoparticulate materials are described, offering magnetic, radionuclide, and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography/single-photon emission commuted tomography (PET/SPECT), and optical imaging. They comprise Fe3O4@NaYF4 core/shell nanoparticles (NPs) with different cation dopants in the shell or core, including Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm). These NPs are stabilized by bisphosphonate polyethylene glycol conjugates (BP-PEG), and then show a high transverse relaxivity (r2) up to 326 mM(-1) s(-1) at 3T, a high affinity to [(18)F]-fluoride or radiometal-bisphosphonate conjugates (e.g., (64)Cu and (99m)Tc), and fluorescent emissions from 500 to 800 nm under excitation at 980 nm. The biodistribution of intravenously administered particles determined by PET/MR imaging suggests that negatively charged Co0.16Fe2.84O4@NaYF4(Yb, Er)-BP-PEG (10K) NPs cleared from the blood pool more slowly than positively charged NPs Fe3O4@NaYF4(Yb, Tm)-BP-PEG (2K). Preliminary results in sentinel lymph node imaging in mice indicate the advantages of multimodal imaging.

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عنوان ژورنال:

دوره 27  شماره 

صفحات  -

تاریخ انتشار 2016